NAD+ Helps Restore Age-Related Muscle Deterioration STORY AT-A-GLANCE Several studies have proposed that mitochondrial dysfunction in your motor neurons drive the development of sarcopenia (age-related muscle loss) Scientists recently discovered that Alzheimer's-like protein aggregates (amyloid beta) underlie the muscle deterioration commonly seen in aging, and that nicotinamide adenine dinucleotide (NAD+) is essential for combating this condition When the NAD+ salvage pathways in muscle are impaired, mitochondrial dysfunction and decreased muscle mass ensue NAD+ boosting molecules such as nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), nicotinamide (a form of vitamin B3 or niacin) and nicotinic acid (niacin) have been shown to protect against age-related muscle disease NMN appears to be the best, as it activates the NAD+ salvage pathway and is a direct precursor to NAD+. Lifestyle strategies such as exercise, sauna bathing, fasting, recalibrating your circadian rh...